The RNA velocity provides a new avenue to study the stemness and lineage of cells in the development in scRNA-seq data analysis. Some promising extensions of it are proposed and the community is experiencing a fast developing period. However, in this stage, it is of prime importance to revisit the whole process of RNA velocity analysis from the mathematical point of view, which will help to understand the rationale and drawbacks of different proposals. The current talk is devoted to this purpose. The overall analysis aims at providing a mathematical basis for more advanced design and development of RNA velocity type methods in the future.
报告人简介: 李铁军,北京大学数学科学学院教授,信息与计算科学系副主任, 国家自然科学基金委优秀青年及杰出青年基金获得者,入选教育部 “新世纪优秀人才”支持计划。研究领域为随机模型及算法。现任及 曾任《Communications in Mathematical Sciences》、《计算数学》、《高 等学校计算数学学报》等杂志编委。多次参加国际、国内学术会议并 作邀请报告。在化学反应随机动力学稀有事件、能量景观、tau-leaping 方法的分析;复杂网络的社区结构;复杂流体多尺度理论及数值分析 方面做出了重要成果。
欢迎大家参加!